PEPTIDES
$99.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that selectively activates the GHS-R1a (ghrelin receptor) to stimulate GH release from the anterior pituitary. As a research peptide, ipamorelin is distinguished by its high selectivity for GH release without significantly affecting cortisol or prolactin levels, making it a valuable tool for studying receptor-specific somatotroph signaling in preclinical models.
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) was developed through systematic structure-activity relationship studies of growth hormone-releasing peptides. Unlike earlier GH secretagogues such as GHRP-6 and GHRP-2, ipamorelin demonstrates remarkable selectivity for GH release without elevating ACTH, cortisol, or prolactin at effective concentrations. The peptide acts as an agonist at the GHS-R1a receptor, a constitutively active GPCR that transduces signals primarily through the Gq/11 pathway. Activation triggers phospholipase C (PLC)-mediated inositol trisphosphate (IP3) generation, intracellular calcium mobilization, and subsequent GH vesicle exocytosis. Published research has confirmed ipamorelin’s selectivity profile across multiple species and experimental paradigms (Raun et al., European Journal of Endocrinology, 1998). This selectivity makes ipamorelin an ideal pharmacological tool for dissecting the specific contribution of GHS-R1a signaling to GH release, independent of confounding hormonal changes.
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) was developed through systematic structure-activity relationship studies of growth hormone-releasing peptides. Unlike earlier GH secretagogues such as GHRP-6 and GHRP-2, ipamorelin demonstrates remarkable selectivity for GH release without elevating ACTH, cortisol, or prolactin at effective concentrations. The peptide acts as an agonist at the GHS-R1a receptor, a constitutively active GPCR that transduces signals primarily through the Gq/11 pathway. Activation triggers phospholipase C (PLC)-mediated inositol trisphosphate (IP3) generation, intracellular calcium mobilization, and subsequent GH vesicle exocytosis. Published research has confirmed ipamorelin’s selectivity profile across multiple species and experimental paradigms (Raun et al., European Journal of Endocrinology, 1998). This selectivity makes ipamorelin an ideal pharmacological tool for dissecting the specific contribution of GHS-R1a signaling to GH release, independent of confounding hormonal changes.
Ipamorelin offers greater selectivity than GHRP-2, which stimulates moderate cortisol and prolactin elevation alongside GH release. GHRP-6 is the least selective of the three, affecting GH, cortisol, prolactin, and appetite signaling. Researchers choose ipamorelin when experimental designs require isolated GHS-R1a-mediated GH stimulation without confounding hormonal changes.
Related products in the Axiom Research Supply catalog: GHRP-2, GHRP-6, Sermorelin.
Reconstitute in bacteriostatic water. Store reconstituted peptide at 2–8°C and use within 30 days. Lyophilized powder at -20°C. Avoid repeated freeze-thaw cycles.
Axiom Research Supply provides Ipamorelin at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | Ipamorelin |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 170851-70-4 |
| Molecular Formula | C38H49N9O5 |
| Molecular Weight | 711.85 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | Growth Hormone Secretagogue (Ghrelin Mimetic) |
| Key Receptor Targets | Growth Hormone Secretagogue Receptor 1a (GHS-R1a) |
| Research Applications | GHS-R1a receptor studies, selective GH release models, appetite signaling research, neuroendocrine pathway studies |
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