PEPTIDES
$99.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
GHRP-6 (Growth Hormone-Releasing Peptide 6) is a synthetic hexapeptide that activates the GHS-R1a receptor to stimulate growth hormone release and appetite-related signaling. As one of the earliest ghrelin-mimetic research peptides, GHRP-6 is widely used in preclinical studies investigating GH secretion, orexigenic pathways, and the broader pharmacology of ghrelin receptor activation.
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) was one of the first synthetic peptides identified to stimulate GH release through the GHS-R1a receptor, predating the discovery of ghrelin itself. This historical significance makes GHRP-6 a foundational tool in growth hormone secretagogue research. The peptide activates GHS-R1a on pituitary somatotroph cells and hypothalamic neurons, stimulating both GH release and appetite signaling through overlapping but distinct pathways. GHRP-6 has a broader hormonal impact than selective secretagogues like ipamorelin, producing measurable increases in cortisol, prolactin, and ACTH alongside GH release. It also strongly stimulates appetite through hypothalamic neuropeptide Y (NPY) and agouti-related peptide (AgRP) pathways. Published research has used GHRP-6 extensively to characterize the ghrelin signaling system and its intersection with energy homeostasis (Smith et al., Science, 1999). Investigators continue to use GHRP-6 when studying the full spectrum of GHS-R1a-mediated physiological responses.
GHRP-6 binds GHS-R1a and activates Gq/11 signaling, triggering PLC, IP3, and calcium mobilization in somatotroph cells. At the hypothalamic level, GHRP-6 activates arcuate nucleus neurons expressing NPY/AgRP, stimulating appetite signaling. The peptide also engages CRH pathways, explaining the observed cortisol and ACTH elevation. The broad activation profile reflects GHRP-6’s ability to engage multiple downstream effectors of GHS-R1a signaling, making it useful for studying the full receptor response rather than isolated GH effects.
GHRP-6 is less selective than both GHRP-2 and Ipamorelin, producing the broadest hormonal and appetite-stimulating effects among common GH secretagogues. This makes it ideal for studying the full pharmacological profile of GHS-R1a activation, while GHRP-2 and Ipamorelin are preferred when researchers need more targeted GH stimulation.
Related products in the Axiom Research Supply catalog: GHRP-2, Ipamorelin, CJC-1295.
Reconstitute in bacteriostatic water. Store reconstituted peptide at 2–8°C. Lyophilized storage at -20°C. Protect from light.
Axiom Research Supply provides GHRP-6 at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | GHRP-6 |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 87616-84-0 |
| Molecular Formula | C46H56N12O6 |
| Molecular Weight | 873.01 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | Growth Hormone-Releasing Peptide (Ghrelin Mimetic) |
| Key Receptor Targets | Growth Hormone Secretagogue Receptor 1a (GHS-R1a) |
| Research Applications | GHS-R1a signaling, appetite regulation studies, GH release models, ghrelin pathway research |
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