PEPTIDES
$89.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment with an added C-terminal Pro-Gly-Pro tripeptide that enhances stability and biological activity. This research peptide modulates neurotrophic factor expression including BDNF and NGF, and engages melanocortin receptor signaling. Semax is studied in preclinical models of neuroprotection, cognitive function, and neurotrophic signaling pathways.
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) was developed at the Institute of Molecular Genetics in Russia as a stable analog of the ACTH(4-10) fragment, which retains neurotropic activity without the adrenocorticotropic effects of full-length ACTH. The C-terminal Pro-Gly-Pro modification protects against carboxypeptidase degradation while maintaining receptor engagement. Research has demonstrated that semax significantly upregulates BDNF and NGF expression in the hippocampus and cortex, enhances TrkB and TrkA receptor signaling, and modulates melanocortin receptor activity (MC3R/MC4R). Published studies have shown semax’s effects on synaptic plasticity, long-term potentiation, and neuroprotective gene expression programs (Dolotov et al., Neuroscience, 2006). The peptide’s combination of melanocortin signaling and neurotrophic factor modulation makes it a multifaceted tool for neuropeptide research.
Semax activates melanocortin receptors (primarily MC3R and MC4R) in the CNS, stimulating cAMP/PKA signaling that drives CREB-mediated transcription of neurotrophic factors. BDNF upregulation activates TrkB receptors, enhancing PI3K/Akt and MAPK/ERK signaling cascades that promote synaptic plasticity and neuronal survival. NGF induction activates TrkA receptors, supporting cholinergic neuron function. Additionally, semax modulates gene expression programs related to the immune response and neuroinflammation in brain tissue, including regulation of chemokines and inflammatory mediators.
Semax modulates neurotrophic factors (BDNF/NGF) through melanocortin receptor activation, while Selank acts through anxiolytic and immune-modulating mechanisms involving the tuftsin tetrapeptide. Dihexa targets HGF/c-Met signaling for synaptic plasticity. Epithalon focuses on telomerase activation and pineal function.
Related products in the Axiom Research Supply catalog: Selank, Epithalon, Dihexa.
Reconstitute in bacteriostatic water. Store reconstituted peptide at 2–8°C. Lyophilized storage at -20°C.
Axiom Research Supply provides Semax at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | Semax |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 80714-61-0 |
| Molecular Formula | C39H53N9O10S |
| Molecular Weight | 831.95 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | Synthetic ACTH(4-10) Analog (Nootropic Peptide) |
| Key Receptor Targets | Melanocortin receptors (MC3R, MC4R); neurotrophic signaling |
| Research Applications | Neurotrophic factor modulation, BDNF/NGF signaling, cognitive function models, neuroprotection research, melanocortin signaling |
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