PEPTIDES
$89.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin peptide produced by the pineal gland. This research peptide has been shown to activate telomerase (hTERT), the enzyme responsible for telomere elongation, and to modulate pineal gland function including melatonin synthesis. Epithalon is studied in preclinical models of cellular senescence, telomere biology, and chronobiology.
Epithalon was developed by Professor Vladimir Khavinson as a synthetic analog of epithalamin, a peptide extract from the pineal gland. The tetrapeptide sequence (Ala-Glu-Asp-Gly) has been shown to activate the expression of the telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of telomerase. Telomerase adds TTAGGG hexameric repeats to chromosome ends, counteracting the progressive telomere shortening that occurs with each cell division. Published research has demonstrated that epithalon treatment increases telomerase activity in human somatic cells and extends the replicative lifespan of cell cultures beyond the Hayflick limit (Khavinson et al., Bulletin of Experimental Biology and Medicine, 2003). Additionally, epithalon has been shown to restore circadian melatonin production in aged animal models, linking pineal function to telomere maintenance. These dual activities make epithalon a unique research tool for studying the intersection of telomere biology and chronobiology.
Epithalon activates hTERT gene transcription, leading to increased expression of telomerase reverse transcriptase protein. Active telomerase binds to telomeric DNA and catalyzes the addition of TTAGGG repeats, maintaining or extending telomere length. The mechanism of hTERT gene activation by epithalon involves modulation of chromatin structure at the hTERT promoter, including effects on histone acetylation and transcription factor access. Separately, epithalon stimulates pineal gland function by modulating melatonin biosynthesis pathways, including effects on serotonin N-acetyltransferase (AANAT) activity, the rate-limiting enzyme in melatonin production.
Epithalon uniquely targets telomerase activation and pineal function, distinguishing it from Semax (neurotrophic factors), Selank (GABAergic/immune modulation), and Dihexa (HGF/c-Met signaling). These peptides address fundamentally different aspects of cellular biology.
Related products in the Axiom Research Supply catalog: Semax, Selank, Dihexa.
Reconstitute in sterile water or bacteriostatic water. Store reconstituted peptide at 2–8°C. Lyophilized storage at -20°C.
Axiom Research Supply provides Epithalon at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | Epithalon |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | Telomerase-Activating Tetrapeptide |
| Key Receptor Targets | Telomerase (TERT) gene activation; pineal gland signaling |
| Research Applications | Telomerase activation studies, telomere length research, pineal function, melatonin regulation, cellular senescence models |
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