PEPTIDES
$99.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the secretin/glucagon superfamily. VIP activates VPAC1 and VPAC2 receptors, Gs-coupled GPCRs that mediate diverse physiological effects including vasodilation, immunomodulation, neuroprotection, and gastrointestinal regulation. As a research peptide, VIP is studied in preclinical models of immune regulation, neuroinflammation, and circadian biology.
VIP was first isolated from porcine intestinal extracts in 1970 and has since been identified as a pleiotropic neuropeptide with widespread distribution in the central and peripheral nervous systems, immune cells, and gastrointestinal tract. VIP signals through two receptor subtypes: VPAC1 (broadly expressed in immune cells, CNS, and liver) and VPAC2 (predominant in smooth muscle, CNS, and endocrine pancreas). Both receptors activate Gs-coupled adenylyl cyclase, elevating cAMP and activating PKA-dependent signaling. Published research has established VIP as a potent immunomodulatory peptide that shifts immune responses from pro-inflammatory Th1/Th17 profiles toward anti-inflammatory Th2/Treg phenotypes (Delgado et al., Pharmacological Reviews, 2004). VIP also functions as a circadian rhythm modulator in the suprachiasmatic nucleus and promotes neuroprotection through cAMP/CREB-mediated survival gene expression.
VIP binds VPAC1 and VPAC2 receptors, activating Gs-alpha and stimulating adenylyl cyclase. Elevated cAMP activates PKA, which phosphorylates CREB and drives transcription of anti-apoptotic and anti-inflammatory genes. In immune cells, VIP suppresses NF-κB activation, reduces TNF-α, IL-6, and IL-12 production, and promotes IL-10 expression. VIP also enhances regulatory T cell differentiation and suppresses Th17 polarization through effects on dendritic cell maturation. In the nervous system, VIP’s cAMP/CREB signaling promotes BDNF expression and neuronal survival.
VIP provides broad immunomodulation through VPAC receptors and cAMP signaling, while KPV targets NF-κB-specific anti-inflammation. BPC-157 focuses on tissue repair through angiogenesis. Selank modulates immune and neurotrophin pathways through a distinct mechanism.
Related products in the Axiom Research Supply catalog: KPV, BPC-157, Selank.
Reconstitute in sterile water or 0.1% BSA solution to prevent adsorption. Store reconstituted peptide at 2–8°C. Lyophilized storage at -20°C.
Axiom Research Supply provides VIP at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | VIP |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 37221-79-7 |
| Molecular Formula | C147H238N44O43S |
| Molecular Weight | 3326.82 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | Vasoactive Intestinal Peptide (Neuropeptide) |
| Key Receptor Targets | VPAC1 and VPAC2 Receptors |
| Research Applications | VPAC receptor signaling, immunomodulation studies, neuroprotection models, gastrointestinal motility research, circadian rhythm studies |
Reviews
There are no reviews yet.