PEPTIDES
$30.00
⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and regulates cellular NAD+ homeostasis. As a research compound, 5-Amino-1MQ is used in preclinical studies examining NNMT’s role in lipogenesis, energy metabolism, and adipocyte differentiation pathways.
5-Amino-1MQ was identified through medicinal chemistry efforts to develop selective NNMT inhibitors. NNMT catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosyl homocysteine (SAH). By inhibiting NNMT, 5-Amino-1MQ prevents the consumption of nicotinamide and SAM, effectively increasing the intracellular pool of NAD+ precursors and preserving the SAM/SAH ratio. Published research has shown that NNMT is overexpressed in adipose tissue and plays a regulatory role in lipogenesis and adipocyte differentiation. Inhibition of NNMT with 5-Amino-1MQ has been demonstrated to alter energy flux in adipocyte models by redirecting nicotinamide toward NAD+ biosynthesis rather than methylation-dependent degradation (Neelakantan et al., Biochemical Pharmacology, 2018). Researchers use this compound to study the intersection of one-carbon metabolism, NAD+ homeostasis, and lipid biology.
5-Amino-1MQ competitively inhibits NNMT by occupying the nicotinamide-binding site. This prevents the methylation of nicotinamide to 1-MNA, preserving intracellular nicotinamide for NAD+ biosynthesis through the salvage pathway. Increased NAD+ availability enhances sirtuin activity (SIRT1/SIRT3), PARP-mediated DNA repair, and mitochondrial oxidative metabolism. Simultaneously, preservation of SAM levels supports global methylation reactions. In adipocyte models, NNMT inhibition has been shown to reduce lipogenic gene expression and alter differentiation programs, linking one-carbon metabolism to fat cell biology.
5-Amino-1MQ targets NNMT enzyme activity, operating through a mechanistically distinct pathway from SLU-PP-332 (ERR agonist for exercise-mimetic effects) and MOTS-C (mitochondrial-derived peptide affecting AMPK). Together, these compounds offer researchers complementary tools for studying different aspects of cellular energy metabolism.
Related products in the Axiom Research Supply catalog: SLU-PP-332, MOTS-C.
Dissolve in DMSO for stock solutions. Store at -20°C. Working solutions in aqueous buffers should be prepared fresh. Protect from light.
Axiom Research Supply provides 5-Amino-1MQ at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.
| Product Name | 5-Amino-1MQ |
| Available Sizes | Multiple dosage options available — see product listing |
| CAS Number | 42464-93-1 |
| Molecular Formula | C11H13NO2 |
| Molecular Weight | 191.23 g/mol |
| Purity | ≥98% (HPLC verified) |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C, protect from light and moisture |
| Peptide Class | NNMT Inhibitor (Small Molecule) |
| Key Receptor Targets | Nicotinamide N-methyltransferase (NNMT) enzyme target |
| Research Applications | NNMT enzyme inhibition, NAD+ metabolism, lipogenesis studies, cellular energy metabolism, adipocyte differentiation models |
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