DSIP

PEPTIDES

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep.

$89.00

⚠️ For Research Use Only — This product is not intended for human consumption. By purchasing, you confirm you are a qualified researcher.

DSIP Research Peptide Overview

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep. This research peptide is studied for its role in sleep architecture modulation, neuroendocrine regulation, and stress response pathways. DSIP is used in preclinical models examining the intersection of sleep physiology and hormonal signaling.

What Is DSIP ?

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was first identified in 1977 by Schoenenberger and Monnier during studies of transmissible sleep factors. The nonapeptide is found in both free and bound forms in the hypothalamus, limbic system, and peripheral tissues. Unlike classical neurotransmitter receptor agonists, DSIP appears to modulate multiple neuroendocrine systems rather than acting through a single identified receptor. Research has demonstrated that DSIP influences slow-wave sleep (delta sleep) patterns, ACTH and cortisol regulation, and LH signaling in preclinical models (Graf & Kastin, Peptides, 1986). The peptide’s mechanism of action remains an active area of investigation, with evidence suggesting involvement in serotonergic, GABAergic, and glutamatergic modulation. DSIP represents a unique research tool for studying the complex neuroendocrine regulation of sleep-wake cycles and stress physiology.

DSIP Mechanism of Action in Research

DSIP’s mechanism of action is multifaceted and not fully characterized. Research suggests the peptide modulates multiple neurotransmitter systems rather than acting through a single receptor. Evidence indicates DSIP may enhance GABAergic inhibitory tone, modulate serotonin receptor activity, and influence glutamatergic signaling in sleep-regulating brain regions. The peptide has also been shown to affect hypothalamic-pituitary-adrenal (HPA) axis activity, modulating ACTH and cortisol release under stress conditions. Its effects on delta sleep are believed to involve modulation of thalamocortical oscillatory circuits that generate slow-wave sleep patterns.

Key Research Applications & Findings

Sleep Architecture Studies:Research has examined DSIP’s effects on slow-wave sleep duration and quality in animal models, investigating its role in delta-wave generation.
Stress Response Modulation: Preclinical studies have investigated DSIP’s modulation of HPA axis activity and cortisol release under acute and chronic stress paradigms.
Neuroendocrine Regulation: Published research has examined DSIP’s effects on LH, ACTH, and GH regulation, exploring its role as a neuroendocrine modulator.
Circadian Rhythm Studies: Investigators use DSIP to study the interaction between sleep-promoting neuropeptides and circadian clock mechanisms.

DSIP Compared with Related Peptides

Unlike Selank and Semax, which act through defined receptor pathways (melanocortin and neurotrophic signaling, respectively), DSIP appears to modulate multiple neuroendocrine systems. Epithalon targets telomerase activation and pineal function, representing a distinct area of neuroendocrine research. DSIP is uniquely positioned for studying the complex neuropharmacology of sleep regulation.

Related products in the Axiom Research Supply catalog: Selank, Semax, Epithalon.

Research & Handling Guidelines

Reconstitute in sterile water. Store reconstituted peptide at 2–8°C and use within 14 days. Lyophilized storage at -20°C. DSIP is sensitive to oxidation; minimize exposure to air.

Why Choose Axiom Research Supply?

Axiom Research Supply provides DSIP at ≥98% (HPLC verified), verified through independent HPLC analysis with third-party testing documentation. Every batch undergoes rigorous quality control including identity confirmation, purity assessment, and endotoxin testing. Our peptides are properly lyophilized and shipped with cold-chain protocols to maintain stability from production to your laboratory. Axiom Research Supply is committed to advancing metabolic peptide science with precision, reproducibility, and dedicated research support. Access our educational resources including the Axiom Research Supply Metabolic Peptide Research eBook for comprehensive scientific background.

Product Name	DSIP
Available Sizes	Multiple dosage options available — see product listing
CAS Number	62568-57-4
Molecular Formula	C35H48N10O15
Molecular Weight	848.81 g/mol
Purity	≥98% (HPLC verified)
Physical Form	Lyophilized Powder
Storage	Store at -20°C, protect from light and moisture
Peptide Class	Neuropeptide (Delta Sleep-Inducing Peptide)
Key Receptor Targets	Multiple neuroendocrine targets (mechanism under investigation)
Research Applications	Sleep architecture research, neuroendocrine modulation studies, stress response models, circadian rhythm studies

What is DSIP used for in research?

DSIP is used in preclinical research to study sleep architecture, neuroendocrine modulation, stress response pathways, and circadian rhythm biology.

What receptor does DSIP target?

DSIP does not act through a single identified receptor. Research suggests it modulates multiple neurotransmitter systems including GABAergic, serotonergic, and glutamatergic pathways.

How should DSIP be stored?

Store lyophilized DSIP at -20°C, protected from light and moisture. Reconstituted DSIP should be refrigerated and used within 14 days. Minimize air exposure.

Is DSIP FDA-approved?

DSIP from Axiom Research Supply is for research use only and has not been approved by the FDA for any medical condition.

What is the molecular weight of DSIP?

DSIP has a molecular weight of approximately 848.81 g/mol.

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